| # | Team | MP | W | D | L | F | A | D | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Louisville City | 34 | 24 | 4 | 6 | 86 | 43 | +43 | 76 |
| 2 | Charleston Battery | 34 | 18 | 10 | 6 | 68 | 35 | +33 | 64 |
| 3 | Detroit City | 34 | 15 | 11 | 8 | 46 | 32 | +14 | 56 |
| 4 | Indy Eleven | 34 | 14 | 9 | 11 | 49 | 50 | -1 | 51 |
| 5 | Rhode Island | 34 | 12 | 15 | 7 | 56 | 41 | +15 | 51 |
| 6 | Tampa Bay Rowdies | 34 | 14 | 8 | 12 | 55 | 46 | +9 | 50 |
| 7 | Pittsburgh Riv… | 34 | 12 | 12 | 10 | 41 | 28 | +13 | 48 |
| 8 | North Carolina | 34 | 13 | 9 | 12 | 54 | 43 | +11 | 48 |
| 9 | Birmingham Legion | 34 | 13 | 6 | 15 | 44 | 51 | -7 | 45 |
| 10 | Hartford Athletic | 34 | 12 | 8 | 14 | 39 | 52 | -13 | 44 |
| 11 | Loudoun United | 34 | 11 | 9 | 14 | 44 | 39 | +5 | 42 |
| 12 | Miami | 34 | 3 | 2 | 29 | 26 | 89 | -63 | 11 |
| Colorado Springs | 1 - 0 | Las Vegas Lights | ||
| Charleston Battery | 1 - 2 | Rhode Island | ||
| Colorado Springs | 1 - 1 | Orange County SC | ||
| Charleston Battery | 2 - 1 | Tampa Bay Rowdies | ||
| New Mexico United | 0 - 1 | Las Vegas Lights | ||
| Louisville City | 0 - 3 | Rhode Island | ||
| New Mexico United | 2 - 1 | Phoenix Rising | ||
| Indy Eleven | 2 - 3 | Rhode Island | ||
| Colorado Springs | 2 - 0 | Oakland Roots | ||
| Louisville City | 3 - 2 | North Carolina | ||
| Detroit City | 1 - 1 | Tampa Bay Rowdies | ||
| Charleston Battery | 1 - 0 | Pittsburgh Riv… | ||
| Memphis 901 | 0 - 0 | Orange County SC | ||
| Las Vegas Lights | 0 - 0 | Sacramento Rep… |